University of Kentucky | College of Pharmacy

Tonglei Li

analyze, compute & design
	solid-state organic/drug chemistry

Tonglei Li, Ph.D.

Invited Talks

(010) face of n,n-octyl-D-gluconamide

Surface Energy of Organic Crystals: Evaluation with AFM, University of Wisconsin, September 21, 2007, Madison, WI
Understanding the Polymorphism of Organic Crystals, University of Kansas, September 4, 2007, Laurence, KS
Fukui Function: A DFT Concept for Understanding the Polymorphism of Organic Crystals, Boehringer Ingelheim, June 29, 2007
Using AFM to Determine Surface Energy of Organic Crystals, Ninth International Workshop on Physical Characterization of Pharmaceutical Solids, June 26, 2007
Aspirin, Still Causing a Headache, Pharmaceutical Sciences Postgraduate Conference, University of Kentucky, April 20, 2007
Understanding Intermolecular Interactions with Density Functional Theory, Department of Chemistry, University of Kentucky, Jan. 12, 2007
Electronic Studies of the Polymorphism of Organic Crystals with Density Functional Theory, AAPS Annual Meeting, Nov. 1, 2006, San Antonio, TX
Understanding Polymorphism of Organic Crystals, Chinese Academy of Sciences Symposium on Computational Chemistry and Parallel Software, July. 11, 2006, Zhang Jia Jie, China
Understanding Crystal Growth with AFM, AAPS Annual Meeting, Nov. 7, 2005, Nashville, TN
Energetic Evaluation of Crystal Surface with Atomic Force Microscopy, Boehringer Ingelheim, Oct. 11, 2005, Danbury, CT
Understanding Crystal-Solvent Interactions with DFT and HSAB, AACP Annual Meeting, July 10, 2005, Cincinnati, OH
Understanding Crystal Growth with Density Functional Theory and HSAB Principle, University of Illinois at Chicago, Mar. 16, 2005, Chicago, IL
Study of Anisotropic Wettability, AAPS Annual Meeting, Nov. 12, 2004, Baltimore, MD
Surface Reconstruction and Crystal Growth, Pfizer, Mar. 24, 2003, Groton, CT
Crystal Engineering for Better Pharmaceutical Materials, Department of Chemical & Materials Engineering, University of Kentucky, Sept. 25, 2002, Lexington, KY
What if Acetaminophen Crystals Need to Relax on the Surface, Molecular Crystallization Consortium, Apr. 17, 2002, Toronto, Canada
Surface Roughness and Fractal Dimension, Upjohn-Pharmacia, Oct. 7, 1998, Kalamazoo, Michigan

Professional Services

Aspirin Crystallization

Editorial Board:

Pharmaceutical Research
Journal of Controlled Release

Meeting Organizer:

Midwest Organic Solid State Chemistry Symposium XVII, Lexington, KY, 2007
“Recent Developments in Pharmaceutical Solid-State Materials,” AAPS 2006

Grant Review Panel:

NSF MWN (Materials World Network) Review Panel (2006)
DOD BCRP/CDRMP BC06 TRN-3 Review Panel (2006)

atomic force microscopy

"Topography"

AFM can be used to probe and obtain the 3-D surface profiles at the nanoscale. We have further applied fractal analysis to evaluate the surface roughness of the measured profiles in order to reveal the intrinsic relationship between the fractal dimension and the underlying processes that produce the materials and form the surface morphologies.

"Etching"

We have studied the etching patterns with AFM of acetaminophen, in particular, the (010) face, in which we have examined the etching following exposure to several difference solvents. It was found that etching patterns were regular and the shape was related to the solvent used for the etching and the underlying crystal-packing motif.

"Surface Energy"

We aim to investigate the use of AFM to measure the surface energy in situ of a model crystal surface upon introducing selected solvents or solutions of tailor-made additives. The AFM is utilized for measuring the adhesion force between an AFM tip and a crystal surface. Based on two different mechanics models, the adhesion force can be related to the work of adhesion, which is related to a series of surface energies, including the crystal-vapor, and most importantly, the crystal-solution interface. Thus by measuring force of adhesion with the AFM solid-liquid surface energy can be determined.

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