Tonglei Li, Ph.D.

The asymmetric unit of the compound contains two molecules and in each of the molecules, the two aromatic rings, lying in two different planes, are bridged by a secondary amino group. This is due to steric hindrance caused by the isopropyl group. Intra- and intermolecular N—H...O hydrogen bonds link the molecules, forming an infinite 1-D tape structure.

The compound contains two aromatic rings linked by an amide group, and adopts a near-planar conformation. There are intra- and intermolecular N—H...O hydrogen bonds, forming centrosymmetric dimers.

The compound forms centrosymmetric dimers via intermolecular hydrogen bonds between carboxylic groups. Weak Cl...Cl interactions further bridge these dimers, leading to infinite chains. In contrast, acid-to-pyridine hydrogen-bonded catemer motifs are observed in both nicotinic acid and 2-chloronicotinic acid. Only intramolecular halogen-bonded S(5) loops exist in 2-chloronicotinic acid.

We aim to develop novel drug delivery systems to improve solubility and reduce side effects associated with non-targeting delivery approaches. By using crystal engineering techniques, we are developing new concepts to deliver anticancer drugs more effectively.